Gout secondary to chronic renal disease: studies on urate metabolism.
نویسندگان
چکیده
منابع مشابه
Gout secondary to chronic renal disease: studies on urate metabolism.
A report of 20 cases of gout considered to be secondary to chronic renal disease is presented. Studies of renal function and of uric acid metabolism were carried out in 16 patients. The daily production of urate remained within normal limits in the face of progressive renal dysfunction. Renal excretion of uric acid was decreased to a mean of 35.5% of the turnover. The cumulative urinary recover...
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The rise in plasma uric acid (UA) in chronic renal failure (CRF) is quite limited. This may be due to either increased extrarenal excretion, diminished biosynthesis, and/or enhanced degradation of uric acid. The intestinal flux studies revealed a striking modification of urate transport from no net flux to a net secretory flux in the jejunum and from a basal net absorptive to a net secretory fl...
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INTRODUCTION Both genetic variation in ATP-binding cassette sub-family G member 2 (ABCG2) and intake of fructose-containing beverages are major risk factors for hyperuricemia and gout. This study aimed to test the hypothesis that the ABCG2 gout risk allele 141 K promotes the hyperuricaemic response to fructose loading. METHODS Healthy volunteers (n = 74) provided serum and urine samples immed...
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INTRODUCTION Two major gout-causing genes have been identified, the urate transport genes SLC2A9 and ABCG2. Variation within the SLC17A1 locus, which encodes sodium-dependent phosphate transporter 1, a renal transporter of uric acid, has also been associated with serum urate concentration. However, evidence for association with gout is equivocal. We investigated the association of the SLC17A1 l...
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Chronic renal failure (CRF) is usually slowly progressive and irreversible impairment of the functional unit of the kidney – the nephron. According to the agreed and established criteria (National Kidney Foundation / Kidney Disease Outcomes Quality Initiative – NKF / KDOQI) there is a five-stage classification, so that in I stage glomerular filtration rate (GFR) > 90 mL/min/1.73m and morphologi...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1980
ISSN: 0003-4967
DOI: 10.1136/ard.39.5.424